Human embryonic stem cells (hESCs) are used to humanize mice. They are also used to generate human tissue, organoids and cells for testing platforms. This chart shows examples of each:
HFH4-hACE2
For more information on this model humanized with fetal clone serum and the HEK293 stem cell line, see this article:
The NIH-funded Mutant Mouse Resource and Research Center (MMRRC) offers this mouse model humanized with fetal clone serum and the HEK293 stem cell line for COVID-19 research. For more information see this article:
hESC-CMs (human embryonic stem cell cardiomyctes)
This example is a testing model of beating cardiomycytes (heart muscle cells) derived from human embryonic stem cells, called hESC-CMs. For more information, see this article:
hPSC-LO (human pluripotent stem cell lung organoid)
A team of researchers from Weill Cornell Medicine and Mount Sinai Hospital developed two novel models of humanized mice using four human embryonic stem cell lines. The first, the hPSC-LO, has human lung organoids.
For more information, see this article:
hPSC-LO (human pluripotent stem cell colonic organoid)
A team of researchers from Weill Cornell Medicine and Mount Sinai Hospital developed two novel models of humanized mice using four human embryonic stem cell lines. The first, the hPSC-LO, has human lung organoids.
For more information, see this article:
hPSC-derived Human Organoids
Six human embryonic stem cells lines were used to create functional human cells, tissues, and organoids. In the project, a human liver organoid was engrafted in a immune deficient mouse. The hPSC-derived human organoids can also be used as testing platforms. For more information, see this article:
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